ࡱ> '`  bjbj C 8Tf<#LP#6$Dz$$$hgLȮ$*#.#"$$Ȯݮ~*~*~*$~*$~*~*ؚ`6 ;28%8\έ0#h%zRN$$~*$$$$$ȮȮ@(>$$$#$$$$d 66 Media Release Next generation fungicide utilises unique chemical structure to boost performance 22 June 2009 NEW information on the chemical structure of a major new fungicide being developed for UK growers is shedding fresh light on reasons behind its strong performance in trials. IZM which was originally announced under its codename of 520 in November 2008, and which contains the active ingredient isopyrazam is undergoing development by Syngenta as a next generation foliar fungicide in cereals and other crops. The important diseases of Septoria tritici and rust in wheat, plus Rhynchosporium, net blotch and Ramularia in barley, are all key targets for its development, says Syngenta UK cereal fungicide manager, Rod Burke, with testing showing it provides repeatedly high yield responses and long-lasting control. Now, latest findings have also shown IZM to provide extended green leaf retention of 7 - 10 days over other materials, adds Mr Burke, and we know green area is a key driver for yield. In addition to that, scientific studies relating to its chemical structure are also allowing us to shed light on why it has given such improved results. Essentially Mr Burke says the IZM molecule consists of two key structural elements. The first, which binds to the fungus, has been newly-classed as belonging to the pyrazole group of chemistry. It is this base pyrazole ring which delivers its broad-spectrum fungicidal activity, he points out. However by adding a second unique ring structure to the molecule known as a benzonorbornene or benz ring he says Syngenta scientists have been able to enhance this with three additional, important characteristics. The unique benzonorbornene ring element of the molecule delivers more powerful binding to the target site of fungus, says Mr Burke, which explains its greater potency against diseases, especially against Septoria tritici and rusts. It offers stronger binding to the leaf wax which accounts for its durable protection, for example against the effects of the weather. Additionally, it also provides superior chemical stability which accounts for its longer-lasting control. In essence, combined together, this benz-pyrazole structure of IZM enables us to explain why it has given broad-spectrum, powerful and long-lasting disease control. New fungicides will be vital for sustaining high crop yields given the concerns about disease resistance or sensitivity shifts to several existing fungicides. As IZM belongs to the benz-pyrazole chemical group, it is also active against strobilurin and triazole-resistant strains of disease. We continue to evaluate this exciting new molecule and will provide updates as work progresses. In addition, IZM has now also been submitted to PSD for UK approval, Mr Burke confirms. Key points IZM next generation fungicide currently undergoing development Targeted against major diseases in wheat and barley High yields and crop greening seen in trials New benz-pyrazole molecule structure identified as reasons for its broad-spectrum, powerful and long-lasting control Photo: Rod Burke with IZM plot Caption: Latest information on the chemical structure of new fungicide IZM is allowing us to explain why it has given broad-spectrum, powerful and long-lasting control of disease, says Syngenta cereal fungicide manager, Rod Burke -ends- For further Press information please contact: Rod Burke Campaign Manager Cereal Fungicides Syngenta Crop Protection UK Ltd Tel: 01223 883444 Mobile: 07721 884677 E-mail:  HYPERLINK "mailto:rod.burke@syngenta.com" rod.burke@syngenta.com Notes for Editors: Syngenta is one of the world's leading companies with more than 24,000 employees in over 90countries dedicated to our purpose: Bringing plant potential to life. Through world-class science, global reach and commitment to our customers we help to increase crop productivity, protect the environment and improve health and quality of life. For more information about us please go to www.syngenta.com.       page  PAGE 3 of  NUMPAGES 3 SyngentaCrop Protection UK Ltd. 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